Publications from CCI Users and Staff University of Gothenburg

Rapporterade fall • Adrenoleukodystrofi - LookForDiagnosis

Magnetic resonance imaging (MRI) of the brain shows characteristic abnormalities. 1998-03-01 Brain slices from 14‐, 17‐, and 21‐day‐old D2, B6, and F., mice were incubated with (3H)galactose and (35S)sulfate. After incubation, microsomes, myelin, and oligodendroglial cells were isolated, and the galactolipids were analyzed. Groups of brains from rats of various ages–7 to 275 days–were analyzed for their contents of galactolipids (cerebroside + cerebroside sulfate), cholesterol, and the individual fatty acids of the gangliosides and glycerophosphatides.

Galactolipids brain

After incubation, microsomes, myelin, and oligodendroglial cells were isolated, and the galactolipids were analyzed. Groups of brains from rats of various ages–7 to 275 days–were analyzed for their contents of galactolipids (cerebroside + cerebroside sulfate), cholesterol, and the individual fatty acids of the gangliosides and glycerophosphatides. Galactolipids are the major class of lipids present in the membranes of plastids and are essential for the synthesis of a functional photosynthetic apparatus (Kobayashi, Kondo, Fukuda, Nishimura, & Ohta, 2007). Galactolipids normally exist in cells that produce and maintain the protective coating of nerve cells (myelin). However, an abundance of galactolipids has a toxic effect. Some galactolipids trigger myelin-forming cells to self-destruct. Other galactolipids are taken up by specialized debris-eating cells in the nervous system called microglia.

However, the detailed study of the brain galactolipids in the patient revealed an elevated ratio of sulfatide/galactocerebroside content, despite the decrease of both lipids. In tissues of other patients with severe demyelinating diseases different from DDS and MLD, this galactolipid ratio was also found to be increased, especially in three patients with adrenoleukodystrophy.

Köp Floxin Märkespiller - Demo

1984-11-01 Galactolipids are the major lipid components of myelin and myelin-competent oligodendrocytes. Chronic Pb exposure may impact on brain development by impairing timely myelin production due to perturbation of the early developmental commitment of oligodendroglial progenitors.

Ulla Lahtinen Personsökning Helsingfors universitet

In addition, galactolipids may be critical in trafficking cell adhesion proteins to the myelin sheath (Kramer et al., 1997). Taken together, it is tantalizing to suggest a role for GalC/sulfatide in mediating the linkage between the axon and the oligodendrocyte at the nodal and paranodal regions and that a disruption in this linkage could yield the structural abnormalities observed in the CGT-deficient mice.

Other galactolipids are taken up by specialized debris-eating cells in the nervous system called microglia. GALC is an enzyme that breaks down molecules called galactolipids, which are heavily present in the brain.
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2008 PHASE-EQUILIBRIA OF MIXTURES OF PLANT GALACTOLIPIDS - THE FORMATION OF A extensively replace phospholipids with galactolipids and sulfolipids Organization and evolution of brain lipidome revealed by large-scale Brain Behav Immun. Brain 140, no.

Nature 293 (5832), 488-490, 1981. distribution of galactolipids has been determined in spinach thylakoid inside-out vesicles obtained Thomas, P.G., Brain, A.P.R., Quinn, P. J. and Williams,.
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Densitometric Groups of brains from rats of various ages–7 to 275 days–were analyzed for their contents of galactolipids (cerebroside + cerebroside sulfate), choles… The fatty acid compositions of galactolipids in neonatal mouse brain gradually changed during the course of myelination. The relative ratio of 2-hydroxy versus nonhydroxy galactolipids was very low at 2 days of age ( approximately 8% of total galactolipids) and increased 6- to 8-fold by 30 days of age. The roles that the myelin galactolipids galactocerebroside (GalC) and sulfatide play in cellular differentiation, myelin formation and maintenance have been investigated for nearly 3 decades. During that time the primary approach has been to perturb lipid activity using antibodies and chemical agents in artificial systems. Recently, the isolation of the gene that encodes UDP-galactose:ceramide The contents of protein and myelin galactolipids were higher in the brains of RJ-administered OVX rats than in the brains of E2-administered OVX rats.

Eva Selstam - Umeå universitet

Phospholipid, cholesterol, and galactolipid are major composition of brain (Calderon et al., 1995; Van Meer et al., 2008), whereas phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and diacylglycerol are well known as lipid second messengers (Ohanian and Ohanian, 2001). Therefore, it is important to maintain adequate lipid levels in the brain. However, the detailed study of the brain galactolipids in the patient revealed an elevated ratio of sulfatide/galactocerebroside content, despite the decrease of both lipids. In tissues of other patients with severe demyelinating diseases different from DDS and MLD, this galactolipid ratio was also found to be increased, especially in three patients with adrenoleukodystrophy.

After incubation, microsomes, myelin, and oligodendroglial cells were isolated, and the galactolipids were analyzed. Consequently, in relation to prenatal levels galactolipids increased most rapidly in the cerebrum, followed by the cerebellum and finally by the brain stem. These regional differences were in clear contrast to data from the rat, as was the finding that only the cerebrum of undernourished children had a galactolipid concentration significantly the cerebrum, have very low values of galactolipids at birth (equivalent to 25 weeks of gestation in the human); and second, the other brain regions show an even faster accretion of galactolipids than the cerebrum. Consequently, it is not surprising that in the rat all the regions, and not only the cerebrum, have been shown to be vulnera- Developing rat brain: Changes in cholesterol, galactolipids, and the individual fatty acids of gangliosides and glycerolphosphatides November 1965 Journal of Lipid Research 6(4):532-6 Myelin was isolated from subcortical areas of ten human brains, with ages ranging from 24 days to 350 days-of-age; samples were subsequently analyzed for lipid composition. Eight infants were victims of Sudden Infant Death Syndrome, and two infants were accident cases. Gray and white matter samples from each brain were also dissected and analyzed. Galactolipids were only 12% of the total We identified three types of radiolabeled galactolipids: type 1 comigrated with MGDG from spinach chloroplasts, type 2 comigrated with monogalactosylcerebrosides (MGCB) from bovine brain, and type 3 comigrated with DGDG from spinach chloroplast (Fig.